Wallaby Genome Project

The Project:

The DNA sequence of the tammar wallaby, a species of kangaroo, occupies the “evolutionary sweet spot” in the tree of life in that it is neatly positioned between mouse and birds. Comparisons of the genetic sequence of man and Tammar wallaby will help identify key regions of the human genome that turn on and off genes and will be major targets for drug action. In addition, the sequence is the vital clue needed to improve our understanding of human development, unlock the molecular basis of milk production as well as explore possible new therapies and preventative treatments. The Australian Genome Research Facility in partnership with the National Institutes of Health in the USA through the Human Genome Sequencing Center, Baylor College of Medicine - Houston, Texas has generated a 2 x coverage of this genome, completed in May 2007.

AGRF Wallaby Genome Project Homepage

Goal/Deliverables:

1) 2 x coverage of the Tammar wallaby (Macropus eugenii) genome. The wallaby genome size is about 3,600,000,000 bases and was sequenced using a whole genome shotgun strategy in the initial stage.

2) The sequence generated now requires assembly in order to enhance its utility as a reference source for biological research.

Why sequence/study the Wallaby genome?

Unlocking the secrets of this novel genome would benefit medicine and agriculture and could lead to treatments for premature birth, better milk production in cows, as well as novel antibiotics and treatments for human diseases.

This project represents a unique opportunity to collaborate at an international level with a prestigious research organization, the National Institutes of Health (NIH), that recognises the inherent scientific (and commercial) value of sequencing the genome of marsupials and that it is willing to accord priority to one of our own emblematic marsupials.

Co-funding the wallaby genome project with the NIH is about partnering with the premier international scientific research institution and the development of international linkages.

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What is the benefit to Australia?
Such partnering/international linkages have substantive economic multiplier effects. Australia has not participated significantly in major scientific projects such as the Human Genome Project. This project represents the opportunity to redress this issue and puts Australian science firmly back on the international genomic map. The further opportunities and benefits that will arise from the linkages created through this endeavour are exceptional. The critical mass in skills, people and equipment brought by a flagship genomics initiative will create the skills and resources to tackle other economically beneficial genomes including: eucalypts, crops, livestock, and pests and diseases.

The Cost:

The Australian Genome Research Facility in partnership with the National Institutes of Health in the USA, generated this sequence a two year period with completion in May 2007. Initial estimates of $10-12 million Australian dollars were indicated for the Australian part of the project. Decreases in price due to efficiencies and economies of scale have reduced the project to the size of $7-8 million prior to the utilization of the new next-generation sequencing technologies.

Contact Information:
Dr. Sue Forrest
Director
PHONE: (03) 9345 2449
FAX: (03) 9345 2678
EMAIL: sue.forrest@agrf.org.au
WEB: www.agrf.org.au